Biostat® RM | Single-use Bioreactor
Biostat® RM is a mixing bioreactor compliant with GMP guidelines. It is used with Flexsafe® RM disposable bags and covers work with a wide range of different cell lines including CHO, HEK293, stem cells and CAR-T cells. Biostat® RM is particularly suitable for working with shear-sensitive cell lines and bioconjugates. The modular concept of the Biostat® RM portfolio, ranging from 2 L to 200 L, provides the flexibility to manage your individual process needs.
Price: On request
Platform Components
A Biostat® RM System Consists of Three Elements: Control Tower, Rocker & Flexsafe® RM Bags
Control tower
Flexibility in process set up
Provides and maintains necessary cultivation conditions, e.g. pressure, temperature, gassing, rocking angle and biocapacitance.
- Control tower fulfills commercial manufacturing norms and regulations, such EN 60204, EN61010, IP 54, CE and UL
- Validated usability in the clean room environment (VHP)
- Possibility to interface to SCADA and DCS systems
Rocker
Modular solution for work flexibility
One rocker platform can be used either with a 20 L or 50 L tray, as well there is a separate 200 L platform. Working volumes range from 100 ml and up to 100 L with Flexsafe® RM bags (e.g., basic, optical, or perfusion configurations)
- Biostat RM® Rockers are available in different versions: Biostat® RM 20|50 or Biostat® RM 200
- wave-motion provides optimal environment for suspension cell culture.
- monitors the fill level of bag precisely, even during rocking
- space-saving
Single-use Bags
Proven for a broad range of different cell lines
Sterile cultivation chamber for various cell lines with multiple build-in control measurements for proper growth conditions
- One Flexsafe® film through whole production process for simplification of product validation
- Optical bags with single-use pH, DO and viable biomass sensors
- Perfusion bags with integrated perfusion membrane or ATF port
Sensors & Analyzers
Precise process control for better parameter definition
The advanced analytics that are a part of the Biostat® RM portfolio ensure defined parameters are met throughout setup and scale up for tight process control.
- achieve advanced parameter definition through unique off-the-shelf Process Analytical Technology (PAT) and control
- Leverage the broad solution of single-use sensors, such as pH, DO, capacitance and conductivity, with BioPAT® Viamass or glucose and lactate with BioPAT® Trace
White Paper: Adopting a Platform Approach to Upstream Processing Increases the Speed to Clinic of New Biopharmaceuticals
