Sartobind® Q | Particle binding and elution

Sartobind® Q absorbent membranes exhibit a macro-porous structure with a pore size > 3 μm. Quaternary ammonium ligands covalently bind to the complete inner surface of the membrane, resulting in the separation of high binding capacity media in combination with extremely high flows.

Viruses and VLP applications:

As the size exclusion effects are negligible, they are suitable for virus purification and show a higher binding ability compared to the resin. Viruses such as adenoviruses or lentiviruses are retained at high flow. This material allows up to > 100 reuse cycles without losing binding capacity.

Application - polishing:

Sartobind Q is the perfect tool for polishing valuable proteins such as monoclonal antibodies. The amounts of the layer can be kept small enough during the removal of virus, DNA, host cell protein, protein A and endotoxin from such pharmaceutical proteins.

Ease of use

• working capacity from 0.08 ml to 5 L
• can be used as a filter

Video content

Traditionally, membrane adsorbers use available filter housings, often ignoring chromatographic process parameters, such as back-mixing effects and elution volume. The new generation of Sartobind® membrane adsorber capsules takes into account these specific requirements and reflects significant advances in binding and elution.