CIM® Monoliths for Preparative Chromatography

CIM® (Convective Interaction Media) monoliths are designed as unique, single-unit structures – making them ideal for purifying very large biomolecules with a very small lab footprint. Large molecules are used commonly in modern gene therapy and vaccines products, and include virus particles, vesicles, RNA, plasmids, and other forms of DNA. These molecules require dedicated solutions for chromatographic purification. The Sartorius family of CIM® monoliths is ideal for preparatory and analytical applications as well as immobilization screening. Pre-configured product packs are also available, a combination of columns and a protocol to suit specific needs.

Monoliths for IEX Chromatography

Benefit from all the attributes of monolithic chromatography with a range of strong and weak anion and cation exchangers to meet the needs for purification of large biomolecules.

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Monoliths for HIC Chromatography

Hydrophobic interaction chromatography (HIC) is a must for nucleic acid separations. When combined with the advantages of monolithic chromatography, HIC meets this need while also providing an excellent solution for the purification of large biomolecules including adenoassociated viruses (AAV).

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Mixed Mode Monolithic Columns

The unique selectivity of mixed-mode monolithic columns ensures the proper purification of the most challenging large biomolecules.

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Monolith Process Packs

Process Packs support the development and scale-up of large molecule purification. They come with recommended CIMmultus® columns and detailed process instructions to achieve high-quality purification in a short time.

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